Cyanoketenes. Synthesis and cycloadditions to formimidates
نویسندگان
چکیده
منابع مشابه
1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.
In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.
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The phosphine-catalyzed [3 + 2]-cycloaddition of 5-methylenehydantoins 4 with the ylides 5, derived from addition of tributylphosphine to the 2-butynoic acid derivatives, 6a-d, gives spiro-heterocyclic products. The camphor sultam derivative 6b gives optically active products. Noteable was that the ylides derived from ethyl 2-butynoate and the 3-(2-butynoyl)-1,3-oxazolidin-2-one derivatives 6c ...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 1978
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)85417-4